Retinal neovascularization and its therapeutic agents

Squalamine improves retinal neovascularization.

PURPOSE Modalities for inhibiting neovascularization may be one avenue to the development of effective therapies for retinopathy. The effect of squalamine, an antiangiogenic amino sterol, on oxygen-induced retinopathy (OIR) was assessed in a mouse model. METHODS OIR was induced in C57BL6 mice by a 5-day exposure to 75% oxygen from postnatal day (P)7 through P12. Squalamine (25 mg/kg, subcutan...

Update on therapeutic neovascularization.

Therapeutic neovascularization for cardiovascular ischemia is a promising avenue in spite of disappointing early clinical trial results. The concept of three different mechanisms of neovascularization has served to define potential therapeutic targets such as vascular remodeling and stem cell recruitment, but it is anticipated that this will lose significance as the pleiotropic nature of angiog...

Histamine and its Releasing Agents

Spontaneous histamine release from isolarted Mastcells was found to be independent of cal­cium in the concentration range up to 1 m. mole/lit. Phosphatidyl serine do not change the effect of calcium on spontaneous release. The activation of anaphyla.ctic histamine release by calcium is potentiated by phosphatidyl serine but the laitter can't do so w1th strontium.  Mastcells, pretreated with AT...

Mechanisms of retinal and choroidal neovascularization.

Retinal neovascularization, collaterals, and vascular shunts.

Retinal vascular disorders are a leading cause ofhuman visual impairment. It is only within the past decade, however, that methodologies such as fluorescein angiography (Novotny and Alvis, I96I) and retinal digestion (Kuwabara and Cogan, I960) have been developed which permit us accurately to delineate the various features of retinal vascular disease. We must remember that retinal vascular resp...